Preheat the oven to 350 degrees F. Lightly butter a 9x13-inch casserole dish or 12-inch Dutch oven.
In a medium bowl, combine the sauce ingredients. Cover and set aside.
In a large cast iron skillet, add half of the meat and season with the Original Seasoning. Cook for about 5 minutes, or until browned. Drain any excess grease and transfer the meat to the casserole dish or Dutch oven. Brown the remaining meat.
Top the first layer of hamburger meat with half of the Big Mac Sauce and half of the cheeses. Repeat to create another layer of meat, sauce and cheese.
Slightly flatten the canned biscuits and evenly place on top of the casserole.
Bake for about 20 to 25 minutes, or until the biscuits are browned. Remove from the oven and brush the biscuits with butter and sprinkle with the sesame seeds. Serve warm.